Data Set of Wilms' Tumor and its Precursor Lesion

Wilms' tumor, or nephroblastoma, accounts for 5% of all cancers in childhood and constitutes the most frequent malignant kidney tumor in children and juveniles. About 75% of all patients are younger than five years - with a peak between two and three years. Nephroblastoma is a solid tumor, consisting mainly of three types of tissue: blastema, epithelium and stroma. In Europe, diagnosis and therapy follow the guidelines of the International Society of Pediatric Oncology (SIOP).
One of the most important characteristics of this therapy protocol is a preoperative chemotherapy. During this therapy, the tumor tissue changes, and a total of nine different subtypes can develop. Depending on this and the local stage, the patient is categorized into one of the three risk groups (low-, intermediate-, or high-risk patients) and further therapy is adapted accordingly. Of course, it would be of decisive importance for therapy and treatment planning to determine the corresponding subtype as early as possible.
In about 40% of all children with nephroblastoma, so-called nephrogenic rests can be detected. Since these only occur in 0.6% of all childhood autopsies, they are considered a premalignant lesion of Wilms' tumors. The diffuse or multifocal appearance of nephrogenic rests is called nephroblastomatosis. Despite the histological similarity, nephroblastomatosis does not seem to have any invasive or metastatic tendencies.
In order to adapt the therapy accordingly and not to expose children to an unnecessary medical burden on the one hand and to maximize their chances of survival on the other, it is necessary to distinguish nephroblastoma and its precursor nephroblastomatosis at the beginning of treatment.

In recent years, the SIOP studies have collected clinical and imaging data from more than 1000 patients, possible through networking of many hospitals. Unfortunately, this has also caused a major problem: The MR images were taken on devices from different manufacturers with different magnetic field strengths over several years. In addition, there are no uniform parameter sets and the individual sequences (of the same type) can vary dramatically.
We have compiled a data set of 202 kidneys (54 nephroblastomatosis, 148 Wilms' tumors) where parameter settings of T2 sequences are as similar as possible. All data sets are T2-weighted images (axial 2D acquisition) with 3.4mm to 9.6mm slice thickness and inslice-sampling ranging from 0.3mm to 1.8mm.

Contact Person:	Sabine Müller
E-mail:	smueller -at- mia.uni-saarland.de
Postal Address:	Mathematical Image Analysis Group
	Faculty of Mathematics and Computer Science,
	Saarland University, Building E1.7
	66123 Saarbrücken, Germany
Office:	Room 4.04 Building E1.7, Saarbrücken Campus

MIA Group
©2001-2023
The author is not
responsible for
the content of
external pages.

Imprint - Data protection